非酒精性脂肪肝的危险因素及脂肪肝诊断的研究进展


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      Neurosurg, 1994 , 81 (1) : 1-9. [ 20 ]   Singla V, Modi M, Singh P, et al. Dolichoectasia of vertebrobasilar system: a rare cause of tic douloureux [ J] . Indian J Med Sci, 2007 , 61 (1) : 30-31. [ 21 ]   Shenouda EF, Coakham HB. Management of petrous endostosis in posterior fossa procedures for trigeminal neuralgia: operative technique [ J] . Neurosurgery, 2007 , 60 (2) : ONS63-ONS69. [ 22 ]   Tatli M, Satici O, Kanpolat Y, et al. Various Surgical modalities for trigeminal neuralgia: literature study of respective long-term out-

Progress in Research of the Risk Factors of Nonalcoholic Fatty Liver and Diagnosis of Fatty Liver  ZHAO Zi-yan, DONG Jing-bo. ( 120 Emergency Center, Tianjin Fifth Center Hospital, Tianjin 300450 , China) Abstract : Fatty liver is a common disease, which may develop into serious diseases such as cirrhosis and the nonalcoholic fatty liver disease ( NAFLD ) is more complex, which is primary liver cancer. Among them, closely related to the inflammatory factor increase, lipid metabolism disorders, atherosclerosis, hypertension, type Ⅱ diabetes and metabolic syndrome. Insulin resistance, obesity, lipid metabolism disorders, and heat ( especially fat )excessive intaking are all important predisposing factors of NAFLD. Liver tissue cell biopsy is the most direct and accurate diagnosis of fatty liver, however, due to the condition limitation, B ultrasonic, CT and 3. 0 T magnetic resonance hydrogen spectrum imaging are all adopted for the diagnosis. Key words: Fatty liver;Nonalcoholic fatty liver;Risk factors;Diagonsis

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comes [ J] . Acta Neurochir( Wien) , 2008 , 150 (3) : 243-255. [ 23 ]   Park JS, Kong DS, Lee JA, et al. Intraoperative management to prevent cerebrospinal fluid leakage after microvascular decompression: Dural closure with a“ plugging muscle ” method [ J] . Neurosurg Rev, 2007 , 30 (2) : 139-142. [ 24 ]   Schaller B. Trigemino-cardiac reflex during microvascular trigeminal decompression in cases of trigeminal neuralgia [ J] . J Neurosurg Anesthesiol, 2005 , 17 (1) : 45-48. 2010-10-28  ???S: 2011-04-12 ???S:

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[ 10 ] 。 IR t? ?p??: l?|2; ?? LM ? ¨; LM??c | 2, ?? 4>? O? ? ? J ] ??~ ?B¨?HI, ?? ?J ? ? ? l ? y? | O, E% ????By?|O?I?e ?B ?? ??。 IR 4 ]?~?¨? HI B?J ?? : ? J? ?B? ?, á?LM?¨;ZJ5l ?? B100 ?? ? :, ?? ( free fatty acid, FFA) ù QlWm |?, áJ5\]| 。 2B????¨> | ? ¨ l W ?? c) é? ) ? NAFLD B ± [ ì ? ( P IR ] NAFLD " W % . j [ 11 , 12 ] 。IR ??e?Bl? y?, o) )? ?ê IR, L v P l W 9:? ?|2, M??mlW?My W?, FFA , 1? ??|2 á?? FFA f|- E ? ? + ¨ ?J5, ZJhi? FFA j? | 2, G| J 5? FFA B?I?A, Z?J5? FFA ? I? ? ·? O, Jh i#??/ ? IG ?, ? ?? l W m4 J 5/B \ “ b>[ì?” 。 á ? I?L l ?B ? l P5Y ], “ b±[ì y?、 ? y??3 ?f | O ??? J 5 [ 13 ] 。á?? · 3 f|? 42 ? 2 ? ? a ? ? _ ?” NAFLD ? 46 ? 2 ? ? a ? ?? _ l W J èé B ! 2 ??a? ? _ l W J èé? YN&¨ià&Z[, IR、 4??B? LM ? ¨;、 l y? àá ?G?, ? ?? ? IR 4 NAFLD ? ? | O % U = ? ? ? B &·。 [ 14 ] 2 . 2  ly?àá  f|??)éBXY ? ? , IR

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May. 2011 , Vol. 17 , No. 10 ’)!" 2011 2 5 ab 17 cb 10 S Medical Recapitulate,

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[1]   Luyckx FH, Lefebvre PJ, Scheen AJ. Non-alconolic steatohepatitis: association with obesity and insulin resistance, and influence of weight loss [ J] . Diabetes Metab, 2000 , 26 (2) : 98-106. [2]   R8@, [ J] . %8 ,w, d)?. l W J BD i? )XY¨? 200425 (7) : 630-631. Di?)?k, [3]   6??, [ J] . ? w ? )? J ? )? m=?. lWJBXY¨? 1999 , 8 (2) : 149-156. k, [4]   %8J5?)±l W J ? ? ? y J ? )9. o ? ? y l W y [ J] . %8J5??k, 2003 , 11 (2) : 71. J?^{&_ [5]   %8J5?)±l W J ? ? ? y J ? )9. ? ? y l W y J [ J] . %8J5??k, 2003 , 11 (2) : 72. ?^{&_ [6]   %8’)±J5? )? ± l W J ? ? ? y J ? )9. o ? ? [ J] . % 8 J 5 ? ? k, 2006 , 14 (3) : ylWyJ?^ N N ? 161-163. [7]   ^?, R ?, ? § ?, 3. 2 ? ? a ? ? _o ? ? y l W J ?¤ [ J] . ??’), 2010 , 22 (2) : 249-251. ???? [8]   Duvnjak M, Leroti I, Barsi N, et al. Pathogenesis and manage[ J] . World J Gasment issues for non-alcoholic fatty liver disease troenterol, 2007 , 13 ( 34 ) : 4539-4550. [9]   Marchesini G, Brizi M, Morselli-Labate AM, et al. Association of nonalcoholic fatty liver disease with insulin resistance [ J] . Am J 1999 , 107 (5) : 450-455. Med, [ 10 ]   5+8. o??yl W J Z ?em XY¨? [ J] . %& i ? f 2004 , 10 (4) : 243. L???, [ 11 ]   Pérez-Aguilar F. Etiopathogenesis of non-alcoholic steatohepatitis [ J] . Gastroenterol Hepatol, 2005 , 28 (7) : 396-406. [ 12 ]   dbI, ??. §^{ 2 ??a?èé ? _o ? ? y l W y J [ J] . % & ? · / ( ? k, 2007 , 27 (3) : ?BU X ? ? ? ? 205-207. [ 13 ]   ?? · , ?=, d?ü. 2 ??a??_o??ylW J B QR [ J] . ??’), 2010 , 31 (5) : 588-589. ?? [ 14 ]   Rashid S, Watanabe T, Sakaue T, et al. Mechanisms of HDL lowering in insulin resistant, hypertriglyceridemic states: the combined effect of HDL triglyceride enrichment and elevated hepatic lipase [ J] . Clin Biochem, 2003 , 36 (6) : 421-429. activity [ 15 ]   Kumar KS, Malet PF. Nonalcoholic steatohepatitis[ J ] . Mayo Clin Proc, 2000 , 75 (7) : 733-739. [ 16 ]   Gochee PA, Jonsson JR, Clouston AD, et al. Steatosis in chronic hepatitis C: association with increased messenger RNA expression of collagen I, tumor necrosis factor-alpha and cytochrome P450 2E1 [ J] . J Gastroenterol Hepatol, 2003 , 18 (4) : 386-392. [ 17 ]   Kohjima M, Enjoji M, Higuchi N, et al. Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver dis[ J] . Int J Mol Med, 2007 , 20 (3) : 351-358. ease [ 18 ]   Romestaing C, Piquet MA, Letexier D, et al. Mitochondrial adaptations to steatohepatitis induced by a methionine-and choline-deficient diet [ J] . Am J Physiol Endocrinol Metab, 2008 , 294 (1) : E110-E119. [ 19 ]   Marrero JA, Fontana RJ, Su GL, et al. NAFLD may be a common underlying liver disease in patients with hepatocellular carcinoma [ J] . Hepatology, 2002 , 36 (6) : 1349-1354. in the United States [ 20 ]   Bugianesi E, Leone N, Vanni E, et al. Expanding the natural history from cryptogenic cirrhosis to hepatoof nonalcoholic steatohepatitis: cellular carcinoma [ J] . Gastroenterology, 2002 , 123 (1) : 134-140. [ 21 ]   Limanond P, Raman SS, Lassman C, et al. Macrovesicular hepatic steatosis in living related liver donors: correlation between CT and histologic findings [ J] . Radiology, 2004 , 230 (1) : 276-280. [ 22 ]   Rinella ME, McCarthy R, Thakrar K, et al. Dual-echo, chemical shift gradient-echo magnetic resonance imaging to quantify hepatic steatosis: Implications for living liver donation [ J] . Liver Transpl, 2003 , 9 (8) : 851-856. [ 23 ]   Machann J, Thamer C, Schnoedt B, et al. Hepatic lipid accumulaa comparative study using spectral fat-setion in healthy subjects: lective MRI and volume-localized 1 H-MR spectroscopy [ J] . Magn Reson Med, 2006 , 55 (4) : 913-917. [ 24 ]   6?y, 7??, ? ?I, 3. M? ~ 1 H T ?? 7 ? ??4? [ J] . % & ’ ) ? ± ? ¤, ?lWJ % ? · ? q B ? | X Y 2004 , 20 ( 10 ) : 1503-1505. 2011-03-14  ???S: 2011-04-22 ???S:

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非酒精性脂肪肝的危险因素及脂肪肝诊断的研究进展
作者: 作者单位: 刊名: 英文刊名: 年,卷(期): 赵紫烟, ZHAO Zi-yan 天津市第五中心医院120急救中心,天津,300450 医学综述 MEDICAL RECAPITULATE 2011,17(10)

参考文献(24条) 1.范明霞;田建明;陆建平 活体~1H磁共振波谱分析在大鼠脂肪肝中应用价值的初步研究[期刊论文]-中国医学影像技术 2004(10) 2.Machann J;Thamer C;Schnoedt B Hepatic lipid accumulation in healthy subjects:a comparative study using spectral fat-selective MRI and volume-localized 1H-MR spectroscopy[外文期刊] 2006(04) 3.Rinella ME;McCarthy R;Thakrar K Dual-echo,chemical shift gradient-echo magnetic resonance imaging to quantify hepatic steatosis:Implications for living liver donation[外文期刊] 2003(08) 4.Limanond P;Raman SS;Lassman C Macrovesicular hepatic steatosis in living related liver donors:correlation between CT and histologic findings[外文期刊] 2004(01) 5.Bugianesi E;Leone N;Vanni E Expanding the natural history of nonalcoholic steatohepatitis:from cryptogenic cirrhosis to hepatocellular carcinoma[外文期刊] 2002(01) 6.Marrero JA;Fontana RJ;Su GL NAFLD may be a common underlying liver disease in patients with hepatocellular carcinoma in the United States[外文期刊] 2002(06) 7.Romestaing C;Piquet MA;Letexier D Mitochondrial adaptations to steatohepatitis induced by a methionine-and choline-deficient diet 2008(01) 8.Kohjima M;Enjoji M;Higuchi N Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease 2007(03) 9.Gochee PA;Jonsson JR;Clouston AD Steatosis in chronic hepatitis C:association with increased messenger RNA expression of collagen I,tumor necrosis factor-alpha and cytochrome P450 2E1[外文期刊] 2003(04) 10.Kumar KS;Malet PF Nonalcoholic steatohepatitis[外文期刊] 2000(07) 11.Rashid S;Watanabe T;Sakaue T Mechanisms of HDL lowering in insulin resistant,hypertriglyceridemic states:the combined effect of HDL triglyceride enrichment and elevated hepatic lipase activity[外文期刊] 2003(06) 12.尤文君;李峰;刘冬娜 2型糖尿病合并非酒精性脂肪肝的临床分析[期刊论文]-吉林医学 2010(05) 13.刘石平;陈晶 新诊断2型糖尿病患者合并非酒精性脂肪性肝病的危险因素分析[期刊论文]-中国实用内科杂志 2007(03) 14.Pérez-Aguilar F Etiopathogenesis of non-alcoholic steatohepatitis 2005(07) 15.王广华 非酒精性脂肪肝发病机制研究进展[期刊论文]-中国康复理论与实践 2004(04) 16.Marchesini G;Brizi M;Morselli-Labate AM Association of nonalcoholic fatty liver disease with insulin resistance[外文期刊] 1999(05) 17.Duvnjak M;Leroti I;Barsi N Pathogenesis and management issues for non-alcoholic fatty liver disease[期刊论 文]-World Journal of Gastroenterology 2007(34) 18.向茜;张伟;李万碧 2型糖尿病合并非酒精性脂肪肝相关因素分析[期刊论文]-西部医学 2010(02) 19.中华医学会肝脏病学分会脂肪肝和酒精性肝病学组 非酒精性脂肪性肝病诊疗指南[期刊论文]-中华肝脏病杂志 2006(03) 20.中华肝脏病学会脂肪肝和酒精性肝病学组 酒精性脂肪性肝病诊断标准 2003(02) 21.中华肝脏病学会脂肪肝和酒精性肝病学组 非酒精性脂肪性肝病诊断标准[期刊论文]-中华肝脏病杂志 2003(02)

22.范建高;曾民德 脂肪肝的研究进展 1999(02) 23.张华捷;庄辉;刘学恩 脂肪肝的流行病学研究进展[期刊论文]-中华流行病学杂志 2004(07) 24.Luyckx FH;Lefebvre PJ;Scheen AJ Non-alconolic steatohepatitis:association with obesity and insulin resistance,and influence of weight loss 2000(02)

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